Extra virgin olive oil: a mapping study of its biological effects
DOI:
https://doi.org/10.63719/imrj.2026.12.01.006Abstract
Extra Virgin Olive Oil (EVOO) is known for its antioxidant, anti-inflammatory, and cardioprotective effects. However, a comprehensive analysis of research trends is still needed to identify funders and collaboration. Therefore, this study aims to examine literatures on EVOO’s biological activities, identifying key contributors, trends, and emerging themes. Data from 894 studies (2004–2024) were extracted from Scopus and analyzed using Scopus Analyser and VOSviewer. The analysis included publication trends, co-authorship networks, keyword co-occurrence, top sponsors, most cited articles and citation patterns by country. Results show steady growth in EVOO research, peaking around 2020. Europe, in particular, Spain and Italy, emerges as the strongest contributor to EVOO research supported by the European Commission and national institutions. The therapeutic effects of EVOO were emphasised in highly cited articles in literature, specifically in the context of cardiovascular protection, neuroprotection, and prevention of the onset of diseases, particularly oleocanthal and hydroxytyrosol appearing as bioactive compounds. Co-authorship analysis reveals clusters of influential researchers, highlighting cross-field collaborations. Keyword indicates a strong focus on antioxidant properties, phenolic compounds and the Mediterranean diet. This study maps the EVOO research landscape, emphasizing its health benefits and scientific significance. By identifying leading studies and emerging trends, it serves as a reference for future research, reinforcing EVOO’s role in nutrition and disease prevention.
References
Reboredo-Rodríguez P, González-Barreiro C, Cancho-Grande B, Simal-Gándara J. Quality of extra virgin olive oils produced in an emerging olive growing area in north-western Spain. Food Chem. 2014;164:418–26.
Servili M, Sordini B, Esposto S, Urbani S, Veneziani G, Di Maio I, et al. Biological activities of phenolic compounds of extra virgin olive oil. Antioxidants. 2014;3(1):1–23.
Lanza B, Ninfali P. Antioxidants in extra virgin olive oil and table olives: Connections between agriculture and processing for health choices. Antioxidants. 2020;9(1).
Oliveras-López MJ, Berná G, Jurado-Ruiz E, López-García de la Serrana H, Martín F. Consumption of extra-virgin olive oil rich in phenolic compounds has beneficial antioxidant effects in healthy human adults. J Funct Foods. 2014;10:475–84. Available from: http://dx.doi.org/10.1016/j.jff.2014.07.013
Ruiz-García I, Ortíz-Flores R, Badía R, García-Borrego A, García-Fernández M, Lara E, et al. Rich oleocanthal and oleacein extra virgin olive oil and inflammatory and antioxidant status in people with obesity and prediabetes. The APRIL study: A randomised, controlled crossover study. Clin Nutr. 2023;42(8):1389–98.
Vazquez A, Sanchez-Rodriguez E, Vargas F, Montoro-Molina S, Romero M, Espejo-Calvo JA, et al. Cardioprotective effect of a virgin olive oil enriched with bioactive compounds in spontaneously hypertensive rats. Nutrients. 2019;11(8).
Micheli L, Bertini L, Bonato A, Villanova N, Caruso C, Caruso M, et al. Role of hydroxytyrosol and oleuropein in the prevention of aging and related disorders: Focus on neurodegeneration, skeletal muscle dysfunction and gut microbiota. Nutrients. 2023;15(7).
Gervasi F and Pojero F. Use of oleuropein and hydroxytyrosol for cancer prevention and treatment: Considerations about how bioavailability and metabolism impact their adoption in clinical routine. Biomedicines. 2024;12(3).
Harun N, Adnyana IK, Damayanti S, Kurniati NF. Administration of oleuropein or hydroxytyrosol improves diabetic markers in obese mice. J Pharm Pharmacogn Res. 2025;13(2):513–26.
Godos J, Scazzina F, Paternò Castello C, Giampieri F, Quiles JL, Briones Urbano M, et al. Underrated aspects of a true Mediterranean diet: understanding traditional features for worldwide application of a “Planeterranean” diet. J Transl Med [Internet]. 2024;22(1):1–22. Available from: https://doi.org/10.1186/s12967-024-05095-w
Gagour J, Hallouch O, Asbbane A, Bijla L, Laknifli A, Lee LH, et al. A Review of recent progresses on olive oil chemical profiling, extraction technology, shelf-life, and quality control. Chem Biodivers. 2024;21(4).
Mousavi S, Mariotti R, Stanzione V, Pandolfi S, Mastio V, Baldoni L, et al. Evolution of extra virgin olive oil quality under different storage conditions. Foods. 2021;10(8):1–19.
Wang Q, Su M. Integrating blockchain technology into the energy sector - From theory of blockchain to research and application of energy blockchain. Comput Sci Rev [Internet]. 2020;37:100275. Available from: https://doi.org/10.1016/j.cosrev.2020.100275
Donthu N, Kumar S, Mukherjee D, Pandey N, Lim WM. How to conduct a bibliometric analysis: An overview and guidelines. J Bus Res [Internet]. 2021;133(April):285–96. Available from: https://doi.org/10.1016/j.jbusres.2021.04.070
Passas I. Bibliometric analysis: The main steps. Encyclopedia. 2024;4(2):1014–25.
Mongeon P, Paul-Hus A. The journal coverage of Web of Science and Scopus : a comparative analysis. Scientometrics. 2016;106:213–28.
Khin Khin Oo NC, Rakthin S. Integrative Review of Absorptive Capacity’s Role in Fostering Organizational Resilience and Research Agenda. Sustain. 2022;14(19):1–27.
Van Eck NJ, Waltman L. VOSviwer manual. Univeristeit Leiden [Internet]. 2013;(January):1–49. Available from: http://www.vosviewer.com/documentation/Manual_VOSviewer_1.6.1.pdf
Beauchamp GK, Keast RSJ, Morel D, Lin J, Pika J, Han Q, et al. Ibuprofen-like activity in extra-virgin olive oil. Nature. 2005;437(7055):45–6.
Martínez-González MA, Salas-Salvadó J, Estruch R, Corella D, Fitó M, Ros E. Benefits of the Mediterranean diet: Insights From the PREDIMED study. Prog Cardiovasc Dis [Internet]. 2015;58(1):50–60. Available from: https://www.sciencedirect.com/science/article/pii/S0033062015000286
Salas-Salvadó J, Bulló M, Estruch R, Ros E, Covas MI, Ibarrola-Jurado N, et al. Prevention of diabetes with Mediterranean diets: a subgroup analysis of a randomized trial. Ann Intern Med. 2014 Jan;160(1):1–10.
Martínez-Lapiscina EH, Clavero P, Toledo E, Estruch R, Salas-Salvadó J, San Julián B, et al. Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial. J Neurol Neurosurg Psychiatry. 2013 Dec;84(12):1318–25.
Romani A, Ieri F, Urciuoli S, Noce A, Marrone G, Nediani C, et al. Health effects of phenolic compounds found in extra-virgin olive oil, by-products, and leaf of olea europaea L. Nutrients [Internet]. 2019;11(8).
Carrasco-Pancorbo A, Cerretani L, Bendini A, Segura-Carretero A, Del Carlo M, Gallina-Toschi T, et al. Evaluation of the antioxidant capacity of individual phenolic compounds in virgin olive oil. J Agric Food Chem. 2005 Nov;53(23):8918–25.
Bogani P, Galli C, Villa M, Visioli F. Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil. Atherosclerosis. 2007 Jan;190(1):181–6.
Abuznait AH, Qosa H, Busnena BA, El Sayed KA, Kaddoumi A. Olive-oil-derived oleocanthal enhances β-amyloid clearance as a potential neuroprotective mechanism against Alzheimer’s disease: in vitro and in vivo studies. ACS Chem Neurosci. 2013 Jun;4(6):973–82.
Martínez-Lapiscina EH, Clavero P, Toledo E, San Julián B, Sánchez-Tainta A, Corella D, et al. Virgin olive oil supplementation and long-term cognition: the PREDIMED-NAVARRA randomized, trial. J Nutr Health Aging. 2013;17(6):544–52.
Babio N, Toledo E, Estruch R, Ros E, Martínez-González MA, Castañer O, et al. Mediterranean diets and metabolic syndrome status in the PREDIMED randomized trial. C Can Med Assoc J = J l’Association medicale Can. 2014 Nov;186(17):E649-57.
Shao J, Huang X, Liu J, Di D. Review characteristics and trends in global olive oil research : A bibliometric analysis. 2022;3311–25.
Garrido-romero M, Díez-municio M, Moreno FJ. Global status , recent trends , and knowledge mapping of olive bioactivity research through bibliometric analysis ( 2000 – 2024 ). 2025;1–19.
Naja F, Hamadeh R. Nutrition amid the COVID-19 pandemic : a multi-level framework for action. Eur J Clin Nutr [Internet]. 2020;1117–21. Available from: http://dx.doi.org/10.1038/s41430-020-0634-3
Altun HK, Seyda M, Ermumcu K, Kurklu NS. Evaluation of dietary supplement , functional food and herbal medicine use by dietitians during the COVID-19 pandemic. 2020;24(5):861–9.
Alkhatib A. Antiviral functional foods and exercise lifestyle prevention of coronavirus. 2020;
Sangma JJD. Future trends in functional foods and nutraceutical development. 2026;07(01).
Moseley W, Rao N, Rosswall T, Sarpong D, Shideed K, María J. Impacts of COVID-19 on food security and nutrition : developing effective policy responses to address the hunger and malnutrition pandemic HLPE issues paper. 2020;(September).
Silva-Soto MÁ, Carrillo-Fernández P, Saez Lancellotti ET, Medina-Jiménez E, Mogaburo Alba JF, Catena-Granados N, et al. Extra virgin olive oil phenolic compounds: Modulating mitochondrial function and protecting against chronic diseases—A narrative review. Nutr . 2025;17(9):1–18.
Barazani O, Dag A, Dunseth Z. The history of olive cultivation in the southern Levant. 2023;(February):1–10.
Besnard G, Terral J frédéric, Cornille A. On the origins and domestication of the olive : a review and perspectives. Ann Bot. 2018;121:385–403.
Ostfeld R and Reiner DM. Seeing the forest through the palms : Developments in environmentally sustainable palm oil production and zero-deforestation efforts. Front Su. 2024;8:1398877.
Ivancic H, Koh LP. Evolution of sustainable palm oil policy in Southeast Asia Evolution of sustainable palm oil policy in Southeast. Cogent Environ Sci [Internet]. 2016;557–558. Available from: http://dx.doi.org/10.1080/23311843.2016.1195032
Fekete M, Lehoczki A, Kryczyk-poprawa A, Zábó V. Functional Foods in modern nutrition science : Mechanisms , evidence , and public health implications. Nutrients. 2025;17:2153.
